RT Journal Article
SR Electronic
T1 DNA analysis: what and when to request?
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 357
OP 360
DO 10.1136/adc.2005.089219
VO 91
IS 4
A1 G Norbury
A1 C J Norbury
YR 2006
UL http://adc.bmj.com/content/91/4/357.abstract
AB Over the last 15 years genetic testing by DNA analysis has expanded enormously both in volume and range due to advances in scientific knowledge and analytical technology. This type of analysis has the potential to provide rapid, cost effective, and accurate diagnostic information but also has its limitations. Some of the changes detected may be of ambiguous consequence and as the knowledge base expands so too does the recognition that other factors can influence the clinical picture. In many cases outcomes may be predicted only on a statistical basis rather than individually. Careful attention should therefore be given to the clinical question that is being addressed before such testing is requested.