@article {Sabin126, author = {M A Sabin and A L Ford and J M P Holly and L P Hunt and E C Crowne and J P H Shield}, title = {Characterisation of morbidity in a UK, hospital based, obesity clinic}, volume = {91}, number = {2}, pages = {126--130}, year = {2006}, doi = {10.1136/adc.2005.083485}, publisher = {BMJ Publishing Group Ltd}, abstract = {Aim: To identify clinical features which predict those most at risk of co-morbidities within an obesity clinic. Methods: Children attending an obesity clinic had fasting glucose, insulin, and lipids measured prior to a standard oral glucose tolerance test (OGTT). History and examination established birth weight, family history of type 2 diabetes/obesity, pubertal status, and presence of acanthosis nigricans. Central and total fat mass was estimated by bio-impedance. Results: Of the 126 children evaluated, 10.3\% (n = 13) had impaired glucose tolerance (IGT); the majority (n = 11) of these would not have been identified on fasting glucose alone. Those with IGT were more likely to have a parental history of type 2 diabetes (relative risk 3.5). IGT was not associated with acanthosis nigricans. Twenty five per cent (n = 19) of those evaluated (n = 75) had evidence of the {\textquotedblleft}metabolic syndrome{\textquotedblright} (MS). HDL cholesterol and triglyceride levels were related to insulin sensitivity (HOMA-R); HDL cholesterol was also related to birth weight SDS. We observed a trend for those with MS to have a lower birth weight SDS. The severity of obesity did not influence the likelihood of IGT or MS. Conclusions: Significant numbers of obese children have associated co-morbidities. Analysis of fasting blood glucose samples alone is not satisfactory to adequately evaluate glucose homoeostasis. The overall level of obesity does not predict co-morbidities. Special attention should be given to those with parental diabetes and a history of low birth weight who are more likely to have IGT and abnormal lipid profiles respectively.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/91/2/126}, eprint = {https://adc.bmj.com/content/91/2/126.full.pdf}, journal = {Archives of Disease in Childhood} }