RT Journal Article SR Electronic T1 Guidelines for the diagnosis and management of cow’s milk protein allergy in infants JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 902 OP 908 DO 10.1136/adc.2006.110999 VO 92 IS 10 A1 Yvan Vandenplas A1 Martin Brueton A1 Christophe Dupont A1 David Hill A1 Erika Isolauri A1 Sibylle Koletzko A1 Arnold P Oranje A1 Annamaria Staiano YR 2007 UL http://adc.bmj.com/content/92/10/902.abstract AB Our aim was to develop guidance for general paediatricians and primary care physicians in diagnosing and managing cow’s milk protein allergy in infants. The guidelines were developed by discussion based on existing national recommendations and standards, clinical experience and, whenever possible, evidence from the literature. Separate algorithms cover breast-fed and formula-fed infants. The recommendations emphasise the importance of comprehensive history taking and careful physical examination. Patients with severe symptoms need to be referred to a specialist. Elimination of cow’s milk protein from the infant’s or mother’s diet and challenges are the gold standard for diagnosis. This guidance is intended as a basis for local discussion, implementation and prospective evaluation. The algorithms should be regularly assessed using clinical audit standards. Once validated, the diagnostic framework could provide a standardised approach in epidemiological and therapeutic studies.