RT Journal Article SR Electronic T1 The investigation and management of chronic neutropenia in children JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 852 OP 858 DO 10.1136/adc.2006.094706 VO 91 IS 10 A1 James, R M A1 Kinsey, S E YR 2006 UL http://adc.bmj.com/content/91/10/852.abstract AB Unravelling the cause of a neutropenia poses a complex diagnostic challenge. The differential diagnosis ranges from life threatening disease to transient benign causes of little clinical significance. This review offers a practical guide to investigating the neutropenic child, and highlights features that merit specialist referral. Therapeutic options, the role of long term follow up, and the complications of severe chronic neutropenia are considered.