TY - JOUR T1 - High tolerance for oral galactose in classical galactosaemia: dietary implications JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 1034 LP - 1036 DO - 10.1136/adc.2003.037671 VL - 89 IS - 11 AU - A M Bosch AU - H D Bakker AU - L J M de B Wenniger-Prick AU - R J A Wanders AU - F A Wijburg Y1 - 2004/11/01 UR - http://adc.bmj.com/content/89/11/1034.abstract N2 - Aim: To study the relevance of restricting the exogenous intake of small amounts of galactose, such as from fruit and vegetables, in patients with classical galactosaemia. Methods: For a period of six weeks, increasing doses of oral galactose to a maximum of 600 mg per day, were added to a very strict galactose restricted diet in three adolescent patients homozygous for the Q188R mutation. During the study, physical examination, including an extended ophthalmic examination, and laboratory studies were performed on a weekly basis. Results: No significant change in any of the studied clinical or biochemical parameters was observed. Conclusions: These findings provide further evidence that attempts to exclude trace amounts of galactose from the diet are not justified. Once the diet is made more liberal, a long term follow up study will be necessary. ER -