TY - JOUR T1 - Familial neurofibromatosis microdeletion syndrome complicated by rhabdomyosarcoma JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 444 LP - 445 DO - 10.1136/adc.87.5.444 VL - 87 IS - 5 AU - A K Lampe AU - G Seymour AU - P W Thompson AU - A Toutain AU - S A Lynch Y1 - 2002/11/01 UR - http://adc.bmj.com/content/87/5/444.abstract N2 - Neurofibromatosis type 1 with dysmorphism and developmental delay is reported in a mother and two children. The son required treatment for a prostatic rhabdomyosarcoma. His sister has an optic pathway glioma. Fluorescence in situ hybridisation confirmed a submicroscopic deletion at 17q11.2. New evidence suggests an increased malignancy frequency in microdeletion cases. ER -