PT - JOURNAL ARTICLE AU - Ng, S M AU - Kumar, Y AU - Cody, D AU - Smith, C S AU - Didi, M TI - Cranial MRI scans are indicated in all girls with central precocious puberty AID - 10.1136/adc.88.5.414 DP - 2003 May 01 TA - Archives of Disease in Childhood PG - 414--418 VI - 88 IP - 5 4099 - http://adc.bmj.com/content/88/5/414.short 4100 - http://adc.bmj.com/content/88/5/414.full SO - Arch Dis Child2003 May 01; 88 AB - Aims: (1) To assess the value of cranial magnetic resonance imaging (MRI) scans in the investigation of girls with central precocious puberty (CPP); and (2) to determine the clinical predictors of abnormal cranial MRI scans in these patients. Methods: A retrospective study of 67 girls diagnosed with CPP who underwent cranial MRI scans at diagnosis. Patients with neurological signs or symptoms at presentation were excluded. Results: The mean age of onset of puberty was 6.2 years (range 2.0–7.9). Intracranial abnormalities were present in 10 (15%) patients (MR+), while 57 (85%) had no abnormalities (MR−). There was no statistical difference between MR+ patients and MR− patients at presentation with respect to age of onset of puberty, pubertal stage, bone age advance, pelvic ultrasound findings, or height or body mass index standard deviation scores (SDS). Conclusion: Girls with CPP should have a cranial MRI scan as part of their assessment since clinical features, including age, are not helpful in predicting those with underlying pathology. Implementation of such an approach may have a substantial effect on clinical practice and healthcare cost.