RT Journal Article
SR Electronic
T1 Lactic dehydrogenase isoenzymes in cerebrospinal fluid of children with Guillain–Barré syndrome
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 255
OP 256
DO 10.1136/adc.87.3.255
VO 87
IS 3
A1 M Nussinovitch
A1 D Prais
A1 Y Finkelstein
A1 D Harel
A1 J Amir
A1 B Volovitz
YR 2002
UL http://adc.bmj.com/content/87/3/255.abstract
AB Background: Increased levels of lactic dehydrogenase (LDH) in the cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. No studies have been performed on patients with Guillain–Barré syndrome (GBS). Aims: To study LDH isoenzymes in CSF of children with GBS. Methods: CSF samples collected from nine patients with GBS were analysed for total LDH isoenzymes activity, and compared to samples from 15 patients with normal results. Results: Mean total LDH activity was 33.33 (6.63) U/l. All patients had significantly increased LDH-3 isoenzyme compared to controls. LDH-3 was the predominant fraction, accounting for more than 50% of total LDH activity and present in more than twice the percentage of LDH-1 or LDH-2. By contrast, in the control group, there were high percentages of mainly LDH-1 and LDH-2. Conclusions: GBS is apparently associated with a distinct LDH isoenzyme pattern in the CSF. More studies are needed to confirm the rise in LDH-3, as serial CSF analyses are unavailable, and to determine the optimum time of analysis when this finding first becomes detectable.