TY - JOUR T1 - Kasabach-Merritt syndrome and interferon alpha: still a controversial issue JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 645 LP - 646 DO - 10.1136/adc.88.7.645-b VL - 88 IS - 7 AU - P Biban Y1 - 2003/07/01 UR - http://adc.bmj.com/content/88/7/645.3.abstract N2 - We read with interest the paper by Akyuz and colleagues,1 which described a 2 year old patient with a Kasabach-Merritt syndrome (KMS) secondary to an infiltrating angiolipoma, who was successfully treated with interferon alpha 2a (IFN-alpha).The authors did not emphasise the increasing body of concerns associated with the use of IFN-alpha in children affected by KMS. Indeed, several authors have recently warned about potential adverse effects related to the use of this drug, the most worrisome being spastic diplegia.2–4Although IFN-alpha has been shown to be an … ER -