PT  - JOURNAL ARTICLE
AU  - Vorstman, E B A
AU  - Anslow, P
AU  - Keeling, D M
AU  - Haythornthwaite, G
AU  - Bilolikar, H
AU  - McShane, M T
TI  - Brain haemorrhage in five infants with coagulopathy
AID  - 10.1136/adc.88.12.1119
DP  - 2003 Dec 01
TA  - Archives of Disease in Childhood
PG  - 1119--1121
VI  - 88
IP  - 12
4099  - http://adc.bmj.com/content/88/12/1119.short
4100  - http://adc.bmj.com/content/88/12/1119.full
SO  - Arch Dis Child2003 Dec 01; 88
AB  - Most intracranial haemorrhages in infants after the neonatal period are secondary to non-accidental injury. Occasionally brain haemorrhages in non-mobile infants are due to an inherited coagulopathy. This may often be diagnosed with a coagulation screen on admission. Little is known about the neurological outcome of infants in the latter group. Five infants are described who presented with acute spontaneous brain haemorrhage secondary to an inherited coagulopathy (n = 3) and vitamin K deficiency in α1 antitrypsin deficiency (n = 1) and Alagille’s syndrome (n = 1). Despite the critical clinical presentation and the severe imaging findings, these five infants made a good neurological recovery. Infants presenting with spontaneous ICH due to a significant (inherited) coagulopathy are usually easy to differentiate from non-accidental shaking injury; their bleeding pattern within the brain seems different from non-accidental shaking injury and neurodevelopment outcome appears better.