PT - JOURNAL ARTICLE AU - Iolo J M Doull TI - Recent advances in cystic fibrosis AID - 10.1136/adc.85.1.62 DP - 2001 Jul 01 TA - Archives of Disease in Childhood PG - 62--66 VI - 85 IP - 1 4099 - http://adc.bmj.com/content/85/1/62.short 4100 - http://adc.bmj.com/content/85/1/62.full SO - Arch Dis Child2001 Jul 01; 85 AB - The median life expectancy for cystic fibrosis is now over 30 years, and it is projected that in newborn infants it will become more than 40 years. The identification of the cystic fibrosis gene and its product, cystic fibrosis transmembrane conductance regulator (CFTR), has widened the spectrum of the disease from the classical case of the infant with cystic fibrosis to the elderly childless man with unexplained bronchiectasis. There is increasing evidence of the advantages of newborn screening for cystic fibrosis and subsequent specialist care. Management concentrates on optimising nutritional status and preventing lung infection and inflammation.