RT Journal Article
SR Electronic
T1 Pancreatic dysfunction in severe obesity
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 261
OP 262
DO 10.1136/adc.84.3.261
VO 84
IS 3
A1 A J Drake
A1 L Greenhalgh
A1 R Newbury-Ecob
A1 E C Crowne
A1 J P H Shield
YR 2001
UL http://adc.bmj.com/content/84/3/261.abstract
AB AIMS To investigate pancreatic function in children attending an obesity clinic.METHODS Thirty six children (of which 34 were white) with severe obesity of prepubertal onset (body mass index more than +2 SDS) were reviewed clinically and dysmorphologically, with assessment of pancreatic function.RESULTS Eight had dysmorphic features and 13 had learning difficulties. Four of 17 prepubertal children had hyperinsulinaemia and seven had hyperproinsulinaemia. All 19 pubertal children had hyperinsulinaemia, 14 had hyperproinsulinaemia, and one had type II diabetes.CONCLUSIONS Metabolic abnormalities predictive of type II diabetes occur in severely obese white children.