RT Journal Article
SR Electronic
T1 Total serum IgE and outcome in infants with recurrent wheezing
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 23
OP 25
DO 10.1136/adc.85.1.23
VO 85
IS 1
A1 F Rusconi
A1 M F Patria
A1 G U Cislaghi
A1 S Sideri
A1 L Gagliardi
YR 2001
UL http://adc.bmj.com/content/85/1/23.abstract
AB OBJECTIVE To investigate the relation between total serum IgE at 0.5–3 and 3–6 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.METHODS Prospective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.RESULTS In the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5–3 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3–6 years were significantly higher in children with positive skin tests (p = 0.013), but were still not associated with recurrence of wheezing.CONCLUSIONS In subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome.