RT Journal Article
SR Electronic
T1 Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 170
OP 171
DO 10.1136/adc.83.2.170
VO 83
IS 2
A1 Tetsushi Yoshikawa
A1 Masaru Ihira
A1 Kyoko Suzuki
A1 Sadao Suga
A1 Tomoyo Matsubara
A1 Susumu Furukawa
A1 Yoshizo Asano
YR 2000
UL http://adc.bmj.com/content/83/2/170.abstract
AB METHODS A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction.RESULTS Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B.CONCLUSION These data suggest that HHV-7 may invade the CNS.