PT  - JOURNAL ARTICLE
AU  - Tetsushi Yoshikawa
AU  - Masaru Ihira
AU  - Kyoko Suzuki
AU  - Sadao Suga
AU  - Tomoyo Matsubara
AU  - Susumu Furukawa
AU  - Yoshizo Asano
TI  - Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms
AID  - 10.1136/adc.83.2.170
DP  - 2000 Aug 01
TA  - Archives of Disease in Childhood
PG  - 170--171
VI  - 83
IP  - 2
4099  - http://adc.bmj.com/content/83/2/170.short
4100  - http://adc.bmj.com/content/83/2/170.full
SO  - Arch Dis Child2000 Aug 01; 83
AB  - METHODS A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction.RESULTS Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B.CONCLUSION These data suggest that HHV-7 may invade the CNS.