RT Journal Article
SR Electronic
T1 Randomised trial of different rates of feeding in acute diarrhoea
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 487
OP 491
DO 10.1136/adc.81.6.487
VO 81
IS 6
A1 Chaomin Wan
A1 Michael R Phillips
A1 Michael J Dibley
A1 Zhengle Liu
YR 1999
UL http://adc.bmj.com/content/81/6/487.abstract
AB OBJECTIVE To compare the effect of different feeding frequencies on the speed of recovery from diarrhoea. METHODS A randomised, non-blinded trial provided 0.452 MJ/kg/day as either 6 or 12 feeds of cows' milk each day to 262 hospitalised male infants aged 3–12 months with acute diarrhoea. Stool frequency, stool weight, body weight, and diarrhoea complications were monitored until recovery or for 14 days. RESULTS A proportional hazards regression model controlling for age, diarrhoea aetiology, and severity of dehydration on admission revealed that the frequently fed group had a significantly shorter duration of diarrhoea (hazards ratio, 1.29; 95% confidence interval, 1.002 to 1.653). Frequently fed infants had a significantly greater weight gain and significantly lower faecal frequency and faecal weight. CONCLUSIONS Breast feeding remains the preferred method of feeding infants with acute diarrhoea, but feeding cows' milk to adequately nourished infants with acute diarrhoea is safe and is more rapidly effective if provided in frequent feeds with low energy loads. In adequately nourished infants 3 to 12 months of age with acute diarrhoea, it is safe to feed cows' milk at either the standard frequency (six feeds each day) or at a higher frequency For adequately nourished infants with acute diarrhoea who are bottle fed cows' milk, the simple clinical manoeuvre of decreasing the volume of each feed and increasing the frequency of feeding (while maintaining the same total daily energy intake) speeds recovery, reduces faecal frequency and faecal weight, and increases weight gain during the recovery period