RT Journal Article
SR Electronic
T1 Weight gain and sudden infant death syndrome: changes in weight z scores may identify infants at increased risk
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 462
OP 469
DO 10.1136/adc.82.6.462
VO 82
IS 6
A1 Peter S Blair
A1 Pam Nadin
A1 Tim J Cole
A1 Peter J Fleming
A1 Iain J Smith
A1 Martin Ward Platt
A1 P J Berry
A1 Jean Golding
A1 the CESDI SUDI research group
YR 2000
UL http://adc.bmj.com/content/82/6/462.abstract
AB AIMS To investigate patterns of infant growth that may influence the risk of sudden infant death syndrome (SIDS). DESIGN Three year population based case control study with parental interviews for each death and four age matched controls. Growth was measured from prospective weight observations using the British 1990 Growth Reference. SETTING Five regions in England (population greater than 17 million, more than 470 000 live births over three years). SUBJECTS 247 SIDS cases and 1110 controls. RESULTS The growth rate from birth to the final weight observation was significantly poorer among the SIDS infants despite controlling for potential confounders (SIDS mean change in weight z score (δzw) = −0.38 (SD 1.40)v controls = +0.22 (SD 1.10), multivariate: p < 0.0001). Weight gain was poorer among SIDS infants with a normal birth weight (above the 16th centile: odds ratio (OR) = 1.75, 95% confidence interval (CI) 1.48–2.07, p < 0.0001) than for those with lower birth weight (OR = 1.09, 95% CI 0.61–1.95, p = 0.76). There was no evidence of increased growth retardation before death. CONCLUSIONS Poor postnatal weight gain was independently associated with an increased risk of SIDS and could be identified at the routine six week assessment. The lower weight of SIDS infants compared to the control infants which was apparent at birth was even more notable in the two weeks before death SIDS infants, particularly those of normal birth weight, exhibited poorer weight gain than their controls Although poor growth was evident among SIDS infants there was no evidence of accelerated retardation in the weeks prior to death The difference in growth between SIDS and control infants was apparent within the first five to seven weeks of life