@article {Galland423, author = {B C Galland and D P G Bolton and B J Taylor and R M Sayers and S M Williams}, title = {Ventilatory sensitivity to mild asphyxia: prone versus supine sleep position}, volume = {83}, number = {5}, pages = {423--428}, year = {2000}, doi = {10.1136/adc.83.5.423}, publisher = {BMJ Publishing Group Ltd}, abstract = {AIMS To compare the effects of prone and supine sleep position on the main physiological responses to mild asphyxia: increase in ventilation and arousal.METHODS Ventilatory and arousal responses to mild asphyxia (hypercapnia/hypoxia) were measured in 53 healthy infants at newborn and 3 months of age, during quiet sleep (QS) and active sleep (AS), and in supine and prone sleep positions. The asphyxial test mimicked face down rebreathing by slowly altering the inspired air: CO2, maximum 5\% and O2, minimum 13.5\%. The change in ventilation with inspired CO2 was measured over 5{\textendash}6 minutes of the test. The slope of a linear curve fit relating inspired CO2 to the logarithm of ventilation was taken as a quantitative measure of ventilatory asphyxial sensitivity (VAS). Sleep state and arousal were determined by behavioural criteria.RESULTS At 3 months of age, prone positioning in AS lowered VAS (0.184 prone v0.269 supine, p = 0.050). At newborn age, sleep position had no effect on VAS. Infants aged 3 months were twice as likely to arouse to the test than newborns (p = 0.013). Placing infants prone as opposed to supine increased the chances of arousal 1.57-fold (p = 0.035).CONCLUSION Our findings show 3 month old babies sleeping prone compared to supine have poorer ventilatory responses to mild asphyxia, particularly in AS, but the increased prevalence of arousal is a protective factor.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/83/5/423}, eprint = {https://adc.bmj.com/content/83/5/423.full.pdf}, journal = {Archives of Disease in Childhood} }