RT Journal Article SR Electronic T1 Urinary N-acetyl-β-d-glucosaminidase in epileptic children treated with antiepileptic drugs JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 420 OP 422 DO 10.1136/adc.83.5.420 VO 83 IS 5 A1 L Csáthy A1 A V Oláh A1 B Clemens A1 I György A1 J Varga YR 2000 UL http://adc.bmj.com/content/83/5/420.abstract AB AIM To investigate the effect of prolonged use of antiepileptic drugs on renal function in children.METHODS Prospective study of 72 children (aged 3–18 years) with epilepsy, on either monotherapy (n = 44) or combined therapy (n = 28). The length of treatment varied from 1 to 13 years. Drugs used were valproic acid, carbamazepine, ethosuximide, clonazepam, clobazepam, and vigabatrin.RESULTS In 65 patients plasma concentrations of the drugs were in the therapeutic range. In the remaining seven, plasma concentrations were slightly high. In 33 patients urinary N-acetyl-β-d-glucosaminidase (NAG) activity was raised. The incidence of pathological NAG indices was significantly higher in the combined therapy group than in the monotherapy group. There were also significant differences in the NAG indices of patients depending on the duration of therapy.CONCLUSIONS Results suggest that chronic use of some antiepileptic drugs—in spite of normal blood concentrations—may alter tubular function, and the dysfunction may result in clinical symptoms. Therefore, we recommend screening of tubular function in these patients.