@article {Behrens68, author = {Rolf Behrens and Thomas Lang and Klaus M Keller and Lutz Bindl and Michael Becker and Burkhard Rodeck and Peter K{\"u}ster and Gerhard F W{\"u}ndisch and Manfred Stolte}, title = {Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial}, volume = {81}, number = {1}, pages = {68--70}, year = {1999}, doi = {10.1136/adc.81.1.68}, publisher = {BMJ Publishing Group Ltd}, abstract = {OBJECTIVE To compare dual therapy (omeprazole and amoxicillin) with triple therapy (omeprazole, amoxicillin, and clarithromycin) in the treatment ofHelicobacter pylori infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared with 2 mg/kg/day. STUDY DESIGN 252 patients (median age, 11.0 years; range, 3{\textendash}18) presenting with chronic abdominal pain underwent endoscopy and a 13C-urea breath test. Gastric biopsy specimens were taken for histological examination and for the rapid urease test. Patients were treated for two weeks: group A (n = 63) received amoxicillin (50 mg/kg; maximum, 2 g/day), group B (n = 73) received amoxicillin and clarithromycin (20 mg/kg; maximum, 1 g/day). Both groups were randomly treated with either 1 or 2 mg/kg omeprazole (maximum, 80 mg/day). Diagnostic procedures were repeated four weeks after the end of treatment. RESULTS 11 patients were excluded; 136 patients were H pyloripositive (56\%), 105 of whom were re-examined after treatment.Helicobacter pylori was eradicated in 52\% of group A and 83\% of group B. The dose of omeprazole had no influence on the eradication rate. Specificity and sensitivity of the rapid urease test were 94\% and 93\%, respectively. Specificity and sensitivity of the 13C-urea breath test were 93\% and 95\%, respectively. CONCLUSIONS Dual therapy can no longer be recommended. Triple therapy is more effective than dual therapy in the eradication of H pylori infection. The lower dose of 1 mg/kg omeprazole was as effective as 2 mg/kg.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/81/1/68}, eprint = {https://adc.bmj.com/content/81/1/68.full.pdf}, journal = {Archives of Disease in Childhood} }