PT - JOURNAL ARTICLE AU - Michael Yung AU - Mike South TI - Randomised controlled trial of aminophylline for severe acute asthma AID - 10.1136/adc.79.5.405 DP - 1998 Nov 01 TA - Archives of Disease in Childhood PG - 405--410 VI - 79 IP - 5 4099 - http://adc.bmj.com/content/79/5/405.short 4100 - http://adc.bmj.com/content/79/5/405.full SO - Arch Dis Child1998 Nov 01; 79 AB - OBJECTIVES To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. STUDY DESIGN Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulised salbutamol. RESULTS The placebo and treatment groups of children were similar at baseline. The 48 children in the aminophylline group had a greater improvement in spirometry at six hours and a higher oxygen saturation in the first 30 hours. Five subjects in the placebo group were intubated and ventilated after enrolment compared with none in the aminophylline group. CONCLUSIONS Aminophylline continues to have a place in the management of severe acute asthma in children unresponsive to initial treatment.