PT  - JOURNAL ARTICLE
AU  - Lancaster, D
AU  - Lennard, L
AU  - Lilleyman, J S
TI  - Profile of non-compliance in lymphoblastic leukaemia
AID  - 10.1136/adc.76.4.365
DP  - 1997 Apr 01
TA  - Archives of Disease in Childhood
PG  - 365--366
VI  - 76
IP  - 4
4099  - http://adc.bmj.com/content/76/4/365.short
4100  - http://adc.bmj.com/content/76/4/365.full
SO  - Arch Dis Child1997 Apr 01; 76
AB  - A nationwide study of intracellular drug metabolite concentrations in children prescribed 6-mercaptopurine for the treatment of lymphoblastic leukaemia was carried out to assess interpatient variability at a standardised dose. Nine children (2% of the total) had completely undetectable metabolites, indicative of non-compliance. Five were adolescents, but otherwise they had no obvious distinguishing characteristics. Not taking any 6-mercaptopurine at all is uncommon, but the problem cannot be predicted. The total number of children who do not comply cannot be determined from this study, but the nine children described represent only a fraction of these.