TY - JOUR T1 - Familial hypothyroidism with autosomal dominant inheritance. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 245 LP - 246 DO - 10.1136/adc.75.3.245 VL - 75 IS - 3 AU - M Mimouni AU - A Mimouni-Bloch AU - J Schachter AU - M Shohat Y1 - 1996/09/01 UR - http://adc.bmj.com/content/75/3/245.abstract N2 - Three generations of a family with clinical and subclinical hypothyroidism caused by thyroid stimulating hormone (TSH) unresponsiveness are described. Findings were low to normal serum thyroxine, raised serum TSH, and low radioiodine uptake; goitre was notably absent. This family is the first evidence of an autosomal dominant mode of transmission of TSH unresponsiveness and may enable identification of the precise defect by genetic linkage study. ER -