PT  - JOURNAL ARTICLE
AU  - Curtis, N
AU  - Zheng, R
AU  - Lamb, J R
AU  - Levin, M
TI  - Evidence for a superantigen mediated process in Kawasaki disease.
AID  - 10.1136/adc.72.4.308
DP  - 1995 Apr 01
TA  - Archives of Disease in Childhood
PG  - 308--311
VI  - 72
IP  - 4
4099  - http://adc.bmj.com/content/72/4/308.short
4100  - http://adc.bmj.com/content/72/4/308.full
SO  - Arch Dis Child1995 Apr 01; 72
AB  - The clinical, pathological, and immunological similarities between Kawasaki disease and the staphylococcal and streptococcal toxic shock syndromes suggest that a superantigen toxin may be involved in the pathogenesis of the disease. The V beta repertoire of peripheral blood mononuclear cells from 21 children with Kawasaki disease, 28 children with other illnesses, and 22 healthy controls were examined using monoclonal antibodies to V beta 2, 5, 8, 12, and 19. The mean percentage of V beta 2 expressing T cells in the patients with Kawasaki disease was increased when compared with healthy controls or children with other illnesses. The mean percentages of V beta 5, 8, 12, and 19 expressing T cells were also increased in the patients with Kawasaki disease compared with healthy controls, but were not increased when compared with children with other illnesses. The selective use of V beta 2 supports the hypothesis that a superantigen is involved in the pathogenesis of Kawasaki disease.