PT  - JOURNAL ARTICLE
AU  - E E Wang
AU  - R Milner
AU  - U Allen
AU  - H Maj
TI  - Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial.
AID  - 10.1136/adc.67.3.289
DP  - 1992 Mar 01
TA  - Archives of Disease in Childhood
PG  - 289--293
VI  - 67
IP  - 3
4099  - http://adc.bmj.com/content/67/3/289.short
4100  - http://adc.bmj.com/content/67/3/289.full
SO  - Arch Dis Child1992 Mar 01; 67
AB  - A randomised double blind trial was conducted to determine the efficacy of inhaled bronchodilators, salbutamol and ipratropium bromide, compared with placebo in the treatment of bronchiolitis. Patients, who were 2 months to 2 years of age and without underlying cardiac or pulmonary disease, received drug 1 (salbutamol or saline placebo) followed one hour later by drug 2 (ipratropium bromide or placebo). Both agents were administered every four hours. The patients were allocated to one of four groups according to a factorial design. The four groups were similar in demographic characteristics, initial oxygenation, and clinical score. The change in oxygen saturation of recipients of both agents was significantly better than that of recipients of salbutamol alone or ipratropium bromide alone. This change, however, was not statistically different from that of the control group. No difference was observed in the clinical score or hospital duration. Inhaled bronchodilators did not improve the condition of hospitalised mild bronchiolitis.