RT Journal Article
SR Electronic
T1 Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 277
OP 279
DO 10.1136/adc.67.3.277
VO 67
IS 3
A1 S Sumimoto
A1 M Kawai
A1 Y Kasajima
A1 T Hamamoto
YR 1992
UL http://adc.bmj.com/content/67/3/277.abstract
AB Plasma tumour necrosis factor-alpha (TNF-alpha) was measured in 15 children with atopic dermatitis, 13 children with bronchial asthma, and 11 healthy controls. Plasma TNF-alpha concentration was increased in atopic dermatitis and the magnitude of the increase was correlated with the severity of the dermatitis but TNF-alpha concentration was not increased in bronchial asthma. A significant correlation was found between plasma TNF-alpha and plasma histamine concentrations in atopic dermatitis. The data suggest that the overproduction of TNF-alpha is associated with increased plasma histamine concentration, and might play a part in the pathophysiological mechanism of atopic dermatitis.