PT  - JOURNAL ARTICLE
AU  - S Sumimoto
AU  - M Kawai
AU  - Y Kasajima
AU  - T Hamamoto
TI  - Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis.
AID  - 10.1136/adc.67.3.277
DP  - 1992 Mar 01
TA  - Archives of Disease in Childhood
PG  - 277--279
VI  - 67
IP  - 3
4099  - http://adc.bmj.com/content/67/3/277.short
4100  - http://adc.bmj.com/content/67/3/277.full
SO  - Arch Dis Child1992 Mar 01; 67
AB  - Plasma tumour necrosis factor-alpha (TNF-alpha) was measured in 15 children with atopic dermatitis, 13 children with bronchial asthma, and 11 healthy controls. Plasma TNF-alpha concentration was increased in atopic dermatitis and the magnitude of the increase was correlated with the severity of the dermatitis but TNF-alpha concentration was not increased in bronchial asthma. A significant correlation was found between plasma TNF-alpha and plasma histamine concentrations in atopic dermatitis. The data suggest that the overproduction of TNF-alpha is associated with increased plasma histamine concentration, and might play a part in the pathophysiological mechanism of atopic dermatitis.