PT  - JOURNAL ARTICLE
AU  - C O'Callaghan
AU  - A D Milner
AU  - A Swarbrick
TI  - Nebulised sodium cromoglycate in infancy: airway protection after deterioration.
AID  - 10.1136/adc.65.4.404
DP  - 1990 Apr 01
TA  - Archives of Disease in Childhood
PG  - 404--406
VI  - 65
IP  - 4
4099  - http://adc.bmj.com/content/65/4/404.short
4100  - http://adc.bmj.com/content/65/4/404.full
SO  - Arch Dis Child1990 Apr 01; 65
AB  - Over a two year period 100 infants with histories of wheeze were challenged with nebulised water. They were sedated and lung function measured by total body plethysmography. Thirteen of the 53 infants who developed bronchoconstriction after challenge with nebulised water were given nebulised sodium cromoglycate and rechallenged with nebulised water. All infants were initially challenged with normal saline, after which there was no significant change in lung function. After challenge with nebulised water and sodium cromoglycate there were significant decreases in specific conductance compared with those found after challenge with normal saline. After rechallenge with nebulised water there was no deterioration in lung function. Although sodium cromoglycate caused a deterioration in lung function in these infants, it protected their airways from challenge with nebulised water.