PT  - JOURNAL ARTICLE
AU  - G Barera
AU  - C Bianchi
AU  - L Calisti
AU  - F Cerutti
AU  - F Dammacco
AU  - E Frezza
AU  - M T Illeni
AU  - L Mistura
AU  - M Pocecco
AU  - F Prisco
TI  - Screening of diabetic children for coeliac disease with antigliadin antibodies and HLA typing.
AID  - 10.1136/adc.66.4.491
DP  - 1991 Apr 01
TA  - Archives of Disease in Childhood
PG  - 491--494
VI  - 66
IP  - 4
4099  - http://adc.bmj.com/content/66/4/491.short
4100  - http://adc.bmj.com/content/66/4/491.full
SO  - Arch Dis Child1991 Apr 01; 66
AB  - IgA and IgG antigliadin antibodies were measured in 498 patients with insulin dependent diabetes mellitus and no history of intestinal malabsorption. Thirty patients had abnormal concentrations of antigliadin antibodies; 22 of these had an intestinal biopsy carried out and 16 of the 22 had subtotal villous atrophy suggestive of coeliac disease (prevalence 3.2%). There were no significant differences between patients with coeliac disease and diabetes and diabetic patients with normal IgA antigliadin antibodies in any of the nutritional variables measured, duration of diabetes, and mean insulin requirement. The mean age of onset of diabetes and attainment of expected height for age were both significantly lower in the patients with both diseases. Typing HLA classes I and II was done in 242 patients. The incidence of HLA-B8, DR3, and DQW2, which are commonly associated with both the diseases, is increased when both are present.