PT  - JOURNAL ARTICLE
AU  - S B van der Meer
AU  - P P Forget
AU  - J W Arends
TI  - Abnormal small bowel permeability and duodenitis in recurrent abdominal pain.
AID  - 10.1136/adc.65.12.1311
DP  - 1990 Dec 01
TA  - Archives of Disease in Childhood
PG  - 1311--1314
VI  - 65
IP  - 12
4099  - http://adc.bmj.com/content/65/12/1311.short
4100  - http://adc.bmj.com/content/65/12/1311.full
SO  - Arch Dis Child1990 Dec 01; 65
AB  - Thirty nine children with recurrent abdominal pain aged between 5.5 and 12 years, underwent endoscopic duodenal biopsy to find out if there were any duodenal inflammatory changes, and if there was a relationship between duodenal inflammation and intestinal permeability to 51Cr-EDTA. Duodenal inflammation was graded by the duodenitis scale of Whitehead et al (grade 0, 1, 2, and 3). In 13 out of 39 patients (33%) definite signs of inflammation were found (grade 2 and 3). Intestinal permeability to 51Cr-EDTA in patients with duodenitis (grade 1, 2, and 3) was significantly higher (4.42 (1.73)%) than in patients with normal (grade 0) duodenal biopsy appearances (3.3 (0.9)%). A significant association was found between duodenal inflammation and abnormal intestinal permeability. Our results give further evidence that there is an intestinal origin of these patients' complaints.