TY - JOUR T1 - Opsonic activity in serum from septic infants treated with intravenous immunoglobulin. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 530 LP - 534 DO - 10.1136/adc.64.4.530 VL - 64 IS - 4 AU - L Maródi AU - A Kalmár AU - I Szabó Y1 - 1989/04/01 UR - http://adc.bmj.com/content/64/4/530.abstract N2 - Thirteen infants with staphylococcal sepsis and reduced opsonic activity received infusions of acid treated immunoglobulin together with antibiotics. Opsonic activity (using Staphylococcus aureus (type 42D) as the test organism), haemolytic activity of complement, and concentrations of complement C3 and IgG were measured in serum prepared before and after three days of treatment with immunoglobulin at a dose of 250-300 mg/kg/day. There was increased ingestion of S aureus by normal human granulocytes in the presence of fresh serum prepared after infusion of immunoglobulin and significantly increased opsonic activity of heat inactivated serum after treatment with immunoglobulin. The haemolytic activity of complement and concentrations of complement C3 were not influenced, and serum concentrations of IgG increased as the result of receiving a total of 800-900 mg/kg immunoglobulin over a period of three days. This study shows that administration of acid treated IgG to septic infants leads to functionally increased opsonisation. ER -