RT Journal Article
SR Electronic
T1 Chronic cough in a hospital population; its relationship to atopy and defects in host defence.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 1593
OP 1598
DO 10.1136/adc.64.11.1593
VO 64
IS 11
A1 H M Lewis
A1 M Haeney
A1 J Jeacock
A1 H Thomas
YR 1989
UL http://adc.bmj.com/content/64/11/1593.abstract
AB The background and aetiology of chronic cough were investigated by comparing 60 children under 6 years with simple cough, 60 children with asthma, and 60 controls. Both cough and asthma were more common in boys and associated with a history of eczema, chest deformity, and skin reactivity to inhaled allergens, but these findings were more prevalent in asthma than cough. House dust mite sensitivity was found in 34 (57%) children with cough, 45 (75%) with asthma, and six (10%) controls. Tests of immunological function showed some high concentrations of IgM in groups with both cough and asthma, but high IgE concentrations, eosinophilia, and lymphocytosis were significant only in asthma. IgG1 and IgG2 concentrations were raised in some children with cough or asthma, but the only low subclass concentrations were of IgG3 observed in the group with cough. Children with simple cough represented a heterogeneous population but many showed evidence of atopy. Major defects of immunity were not observed.