@article {Patel970, author = {H R Patel and S A Bhave and A N Pandit and M S Tanner}, title = {Copper in urine and hair in Indian childhood cirrhosis.}, volume = {63}, number = {8}, pages = {970--972}, year = {1988}, doi = {10.1136/adc.63.8.970}, publisher = {BMJ Publishing Group Ltd}, abstract = {In advanced Indian childhood cirrhosis (ICC) urine copper concentration was higher (range 416-103,448 mg/g creatinine) than in other hepatic diseases (range 67-10,303 mg/g creatinine). In early ICC urine copper concentration was more modestly raised (1188-9470 mg/g creatinine), but rose to high values (2222-42,819 mg/g creatinine) after a single dose of penicillamine 20 mg/kg. A post-penicillamine urinary copper:creatinine ratio greater than 10,000 mg/g supports a diagnosis of ICC. The concentration of copper in the hair, while increased in advanced ICC, is of no diagnostic value in early cases.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/63/8/970}, eprint = {https://adc.bmj.com/content/63/8/970.full.pdf}, journal = {Archives of Disease in Childhood} }