RT Journal Article
SR Electronic
T1 Cytogenetic investigations of solid tumours of children.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 1012
OP 1015
DO 10.1136/adc.63.9.1012
VO 63
IS 9
A1 A D Pearson
A1 M M Reid
A1 E V Davison
A1 N Bown
A1 A J Malcolm
A1 A W Craft
YR 1988
UL http://adc.bmj.com/content/63/9/1012.abstract
AB The association of non-random chromosome abnormalities with solid tumours of childhood may improve accuracy of diagnosis and prognosis and lead to a better understanding of their biology. In a pilot study in the Northern region of England fresh tumour biopsy specimens were obtained from 39 to 72 consecutive solid tumours in children who presented over a period of 21 months. Cytogenetic analysis was possible in 33 and clonal chromosomal abnormalities were detected in nine. In addition, seven of 10 tumours investigated after treatment were abnormal. Ten of these 16 abnormal karyotypes have not previously been described. This pilot study has shown that a concerted investigation of tumour cytogenetics is possible. A multicentre study is essential if our knowledge of basic tumour cytogenetics is to progress.