PT  - JOURNAL ARTICLE
AU  - R Denays
AU  - M Rubinstein
AU  - H Ham
AU  - A Piepsz
AU  - P Noël
TI  - Single photon emission computed tomography in seizure disorders.
AID  - 10.1136/adc.63.10.1184
DP  - 1988 Oct 01
TA  - Archives of Disease in Childhood
PG  - 1184--1188
VI  - 63
IP  - 10
4099  - http://adc.bmj.com/content/63/10/1184.short
4100  - http://adc.bmj.com/content/63/10/1184.full
SO  - Arch Dis Child1988 Oct 01; 63
AB  - Fourteen children with various seizure disorders were studied using a cerebral blood flow tracer, 123I iodoamphetamine (0.05 mCi/kg), and single photon emission computed tomography (SPECT). In the five patients with radiological lesions, SPECT showed congruent or more extensive abnormalities. Five of the nine children with a normal scan on computed tomography had abnormal SPECT studies consisting of focal hypoperfusion, diffuse hemispheric hypoperfusion, multifocal and bilateral hypoperfusion, or focal hyperperfusion. A focal lesion seen on SPECT has been found in children with tonic-clonic seizures suggesting secondarily generalised seizures. Moreover the pattern seen on SPECT seemed to be related to the clinical status. An extensive impairment found on SPECT was associated with a poor evolution in terms of intellectual performance and seizure frequency. Conversely all children with a normal result on SPECT had less than two seizures per year and normal neurological and intellectual development.