TY - JOUR T1 - Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 938 LP - 940 DO - 10.1136/adc.62.9.938 VL - 62 IS - 9 AU - R von Kries AU - S Kreppel AU - A Becker AU - R Tangermann AU - U Göbel Y1 - 1987/09/01 UR - http://adc.bmj.com/content/62/9/938.abstract N2 - The effect of prophylaxis with oral vitamin K (1 mg vitamin K1 given with the first feed) on the rate of detection of acarboxyprothrombin (PIVKA II) and factor II clotting concentration [corrected] were analysed. Introducing such prophylaxis reduced the rates of detection of PIVKA II concentration [corrected] on day 5 from 48% to zero. None of the babies given prophylaxis had factor II clotting concentration [corrected] below 40%, compared with 34 of 95 babies not given prophylaxis. This study has important implications in the prophylaxis of both classical and late onset haemorrhagic disease of the newborn. ER -