TY - JOUR T1 - Recurrent neural tube defects, risk factors and vitamins. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 440 LP - 444 DO - 10.1136/adc.61.5.440 VL - 61 IS - 5 AU - J Wild AU - A P Read AU - S Sheppard AU - M J Seller AU - R W Smithells AU - N C Nevin AU - C J Schorah AU - D W Fielding AU - S Walker AU - R Harris Y1 - 1986/05/01 UR - http://adc.bmj.com/content/61/5/440.abstract N2 - Data from our trial of periconceptional vitamin supplementation for the prevention of neural tube defects have been analysed to assess the influence of various factors on recurrence rates of neural tube defect. Our data suggest that the risk of recurrence of neural tube defect is influenced by the number of previous neural tube defects, area of residence, immediately prior miscarriage, and interpregnancy interval. None of these factors, however, contributed any significant differential risk between supplemented and unsupplemented mothers. Hence we conclude that the highly significant difference in recurrence rates of neural tube defect between supplemented and unsupplemented mothers was due to vitamin supplementation. ER -