RT Journal Article
SR Electronic
T1 Interleukin-1 in malnutrition.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 182
OP 185
DO 10.1136/adc.61.2.182
VO 61
IS 2
A1 Bhaskaram, P
A1 Sivakumar, B
YR 1986
UL http://adc.bmj.com/content/61/2/182.abstract
AB The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.