PT  - JOURNAL ARTICLE
AU  - P Bhaskaram
AU  - B Sivakumar
TI  - Interleukin-1 in malnutrition.
AID  - 10.1136/adc.61.2.182
DP  - 1986 Feb 01
TA  - Archives of Disease in Childhood
PG  - 182--185
VI  - 61
IP  - 2
4099  - http://adc.bmj.com/content/61/2/182.short
4100  - http://adc.bmj.com/content/61/2/182.full
SO  - Arch Dis Child1986 Feb 01; 61
AB  - The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.