TY - JOUR T1 - Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 1114 LP - 1120 DO - 10.1136/adc.61.11.1114 VL - 61 IS - 11 AU - M M Brett AU - A T Ghoneim AU - J M Littlewood Y1 - 1986/11/01 UR - http://adc.bmj.com/content/61/11/1114.abstract N2 - Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20,500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis. ER -