RT Journal Article SR Electronic T1 Pulmonary interstitial emphysema in very low birthweight infants. JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 612 OP 615 DO 10.1136/adc.58.8.612 VO 58 IS 8 A1 S M Hart A1 M McNair A1 H R Gamsu A1 J F Price YR 1983 UL http://adc.bmj.com/content/58/8/612.abstract AB Forty six of 142 infants weighing less than 1500 g at birth, who had chest radiographs in the first 5 days of life, developed pulmonary interstitial emphysema (PIE) and in 19 this occurred in the first 24 hours. PIE was seen more frequently in infants weighing less than 1000 g at birth (24 of 57) than in those weighing 1000-1500 g (22 of 85). Ventilation for hyaline membrane disease was strongly associated with PIE, and only babies who were resuscitated, or ventilated, or had hyaline membrane disease developed the disorder. Most pneumothoraces were preceded by x-ray appearances of PIE (17 of 21). Mortality was increased in ventilated infants who developed PIE and was high in those with severe x-ray changes.