%0 Journal Article %A M H Bellman %A E M Ross %A D L Miller %T Reye's syndrome in children under three years old. %D 1982 %R 10.1136/adc.57.4.259 %J Archives of Disease in Childhood %P 259-263 %V 57 %N 4 %X The National Childhood Encephalopathy Study identified 37 cases of Reye's syndrome in children aged between 2 and 36 months in a 3-year period, giving an estimated incidence in Great Britain of 0.7/100 000 children a year. The diagnostic features were neither consistently positive in these cases, nor negative in 11 others later considered not to have Reye's syndrome. The prognosis was poor; the fatality rate was 46%, and 60% of the survivors were handicapped. A surveillance scheme to investigate pathological, clinical, and epidemiological factors in this rare condition is required. This has now been set up in the UK. %U https://adc.bmj.com/content/archdischild/57/4/259.full.pdf