PT - JOURNAL ARTICLE AU - Y Ishimaru AU - S Nakano AU - K Yamaoka AU - S Takami TI - Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. AID - 10.1136/adc.55.8.583 DP - 1980 Aug 01 TA - Archives of Disease in Childhood PG - 583--588 VI - 55 IP - 8 4099 - http://adc.bmj.com/content/55/8/583.short 4100 - http://adc.bmj.com/content/55/8/583.full SO - Arch Dis Child1980 Aug 01; 55 AB - In Japan we have had two outbreaks of hand, foot, and mouth disease associated with disorders of the central nervous system, one in 1973 and the other in 1978. The isolated virus in both outbreaks was enterovirus 71. Central nervous system disorders were present in 24% of patients in 1973 and in 8% of patients in 1978. These disorders were localised encephalitis with cerebellar signs as the main feature, aseptic meningitis, and polio-like paresis. The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies. However in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.