RT Journal Article
SR Electronic
T1 Hypothalamic-pituitary-gonadotropic function in girls with premature thelarche.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 941
OP 944
DO 10.1136/adc.55.12.941
VO 55
IS 12
A1 A M Pasquino
A1 F Piccolo
A1 A Scalamandre
A1 M Malvaso
A1 R Ortolani
A1 B Boscherini
YR 1980
UL http://adc.bmj.com/content/55/12/941.abstract
AB Hypothalamic-pituitary-gonadotropic activity was investigated in 9 girls with premature thelarche, and compared with that in 9 healthy girls and 6 girls with true precocious puberty. The gonadotropin stimulation test with luteinising hormone-releasing hormone was used. Girls with premature thelarche showed luteinising hormone response resembling that of normal girls, and follicle-stimulating hormone (FSH) response quite similar to that of girls with precocious puberty. This suggests that in premature thelarche there is a partial activation of the diencephalic-hypophyseal-gonadal axis, which affects FSH only. Premature thelarche therefore, should be considered as one of the disorders due to altered sensitivity of the hypothalamic receptors which regulate sex maturation.