RT Journal Article
SR Electronic
T1 Chloramphenicol and phenobarbitone--a drug interaction.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 76
OP 77
DO 10.1136/adc.54.1.76
VO 54
IS 1
A1 Bloxham, R A
A1 Durbin, G M
A1 Johnson, T
A1 Winterborn, M H
YR 1979
UL http://adc.bmj.com/content/54/1/76.abstract
AB Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.