PT  - JOURNAL ARTICLE
AU  - Bloxham, R A
AU  - Durbin, G M
AU  - Johnson, T
AU  - Winterborn, M H
TI  - Chloramphenicol and phenobarbitone--a drug interaction.
AID  - 10.1136/adc.54.1.76
DP  - 1979 Jan 01
TA  - Archives of Disease in Childhood
PG  - 76--77
VI  - 54
IP  - 1
4099  - http://adc.bmj.com/content/54/1/76.short
4100  - http://adc.bmj.com/content/54/1/76.full
SO  - Arch Dis Child1979 Jan 01; 54
AB  - Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.