PT  - JOURNAL ARTICLE
AU  - E E Tyrala
AU  - W E Dodson
TI  - Caffeine secretion into breast milk.
AID  - 10.1136/adc.54.10.787
DP  - 1979 Oct 01
TA  - Archives of Disease in Childhood
PG  - 787--800
VI  - 54
IP  - 10
4099  - http://adc.bmj.com/content/54/10/787.short
4100  - http://adc.bmj.com/content/54/10/787.full
SO  - Arch Dis Child1979 Oct 01; 54
AB  - Serum and milk concentrations of caffeine were measured in 5 breast-feeding mothers after a standardised oral dose of caffeine. Peak concentrations of caffeine in serum and milk were attained 60 minutes later. Binding of caffeine by constituents of serum and breast milk was low (25 and 3.2% respectively). In breast milk, caffeine binding is associated with the cream layer, and correlates with the butter fat content. Caffeine does not diffuse freely into breast milk and concentrations in milk are lower than in maternal serum.