PT - JOURNAL ARTICLE AU - A Pertzelan AU - Z Laron AU - M Adler-Bier AU - R Prager-Lewin AU - H Kaufman TI - Gonadotrophin release in untreated congenital virilising adrenal hyperplasia. AID - 10.1136/adc.53.4.305 DP - 1978 Apr 01 TA - Archives of Disease in Childhood PG - 305--307 VI - 53 IP - 4 4099 - http://adc.bmj.com/content/53/4/305.short 4100 - http://adc.bmj.com/content/53/4/305.full SO - Arch Dis Child1978 Apr 01; 53 AB - A 9.9-year-old boy and a 9.8-year-old girl with virilising congenital adrenal hyperplasia were subjected to an IV LH-RH (luteinising hormone-releasing hormone) test (so microgram/m2 before initition of therapy with corticosteroids. The pattern of response of LH and follicle-stimulating hormone to LH-RH was found to correspond to the stage of their precocious sexual development and advanced bone age, but not to their chronological age. This finding has implications with regard to the mechanism controlling gonadotrophin secretion at puberty.