RT Journal Article
SR Electronic
T1 Hypothalamo-pituitary hormone insufficiency associated with cleft lip and palate.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 952
OP 955
DO 10.1136/adc.53.12.952
VO 53
IS 12
A1 A Roitman
A1 Z Laron
YR 1978
UL http://adc.bmj.com/content/53/12/952.abstract
AB Two male patients with congenital cleft lip and palate first seen at ages 10.2 and 21.5 years presented with typical signs of hypothalamic-interior pituitary hormone deficiencies. They were found to lack GH, LH, and FSH and to be partially deficient in TSH and ACTH. Several congenital defects may explain this rare syndrome affecting midline structures in the proximity of the maldeveloped palate, including Rathke's pouch, which migrates distally to develop into the anterior pituitary.