PT  - JOURNAL ARTICLE
AU  - Aranda, J V
AU  - Collinge, J M
AU  - Zinman, R
AU  - Watters, G
TI  - Maturation of caffeine elimination in infancy.
AID  - 10.1136/adc.54.12.946
DP  - 1979 Dec 01
TA  - Archives of Disease in Childhood
PG  - 946--949
VI  - 54
IP  - 12
4099  - http://adc.bmj.com/content/54/12/946.short
4100  - http://adc.bmj.com/content/54/12/946.full
SO  - Arch Dis Child1979 Dec 01; 54
AB  - The developmental changes in caffeine elimination were studied in 7 infants aged between 2 1/2 weeks and 6 months. Adult plasma clearance rate of caffeine was achieved at 3 to 4 1/2 months of age. Plasma half-life and elimination rate reached adult levels after 3 to 4 1/2 months and seemed to exceed adult capacity thereafter. No significant changes in apparent volume of distribution were noted. Our data provide some indication of the age in infancy when the low rates of caffeine elimination in the neonate increase to the adult rate.